Mercedes W220 Window Rear Door Guide Rail Seal Frame Right O/S Side A2207350425

Mercedes W220 Window Rear Door Guide Rail Seal Frame Right O/S Side is a precisely fitted body component designed for the rear right door area of the W220 S-Class generation. It is responsible for the tight seating of the window frame, noise reduction, and protecting the interior from moisture, which translates into stable acoustic comfort and the durability of the upholstery. This solution is dedicated to users who want to maintain factory-quality fitment and proper window operation in their Mercedes.

Specifications and technical data

• SKU: A2207350425
• Mark: Mercedes (Genuine OE)
• Condition: Used
• OEM Part Number: A2207350425
• Substitutable numbers: A2207350425, A 220 735 04 25
• Location on the vehicle: Rear, Right
• Part type: Door Seal
• Category: Door Seals

Function and application of the window frame seal

The window frame seal in the rear right door is responsible for the proper guidance and sealing of the window where it meets the door frame. In practice, this means:

• limiting the ingress of water and moisture into the door interior and cabin,
• reducing wind noise at higher speeds,
• stable window guidance during raising and lowering,
• protecting the window edge from excessive vibrations. Thanks to its proper profile and fitment to the rear right side of the body, the seal helps maintain body line consistency and proper window adhesion to the door frame.

Compatibility and fitment for Mercedes W220

The presented seal has been designed specifically for Mercedes S-Class W220 models in the rear right door configuration. This means that its geometry, cross-sectional shape, and mounting points are adapted to the factory window frame in this specific body style. Such fitment allows for:

• installation in place of the original component without modifications,
• maintaining proper window pressure against the frame,
• maintaining factory levels of sealing and driving comfort. For users who value original Mercedes construction solutions, this is particularly important for post-collision repairs, replacing corroded door components, or eliminating leaks.

Component characteristics and benefits of installation

The window frame seal in the rear right part of the body works under demanding conditions – it is exposed to temperature changes, UV radiation, water, and constant window movement. A properly selected component helps restore:

• stable operation of the window lifting mechanism,
• even pressure around the entire frame circumference,
• aesthetic appearance of the door edge without deformations or gaps. Replacing a worn or brittle seal with a properly fitted component helps eliminate common symptoms such as wind whistling, water streaks near the door upholstery, or loose window operation. It is a practical solution for those who want to restore factory sealing parameters in their Mercedes in a controlled manner.

Installation zone: rear – right side of the vehicle

The component is intended for installation in the rear right part of the body, which is important both when selecting parts and when planning service work. Correctly identifying the vehicle side minimizes the risk of ordering errors and speeds up the installation process. In practice, installing the seal in this zone involves:

• accessing the window frame in the rear right door,
• removing the old sealing component,
• seating the new seal in the factory-provided slots. This approach allows for maintaining structural consistency of the door and proper interaction of the seal with other window guidance components.

Why choose this seal for your Mercedes

Choosing a dedicated window frame seal for the Mercedes W220 is a solution aimed at users who want to maintain the high standard of finish characteristic of this vehicle class. A properly selected component:

• helps maintain acoustic comfort inside the cabin,
• limits the risk of moisture affecting upholstery and metal parts,
• supports the proper operation of the window mechanism in the rear right part of the body. Thanks to this, repair in the door area is not just a replacement of a worn component, but a conscious restoration of functionality in accordance with the manufacturer's specifications. If you are planning a comprehensive repair or upgrade of the door area in your Mercedes and need other components from the same group, such as window frame seals, perimeter seals, or additional sealing profiles, check the available parts in the Mercedes door seals category.